Many issues associated with heavy drinking are that your brain's communication pathways are interfered with. Communication between neurotransmitters have slowed down. Damage in the Cerebellum occurs, which is why you stumble around after a few drinks, and your cognitive functions are impaired. Damage to the Cerebral Cortex also happens and our ability to think, plan, behave properly, and act socially decrease.
Heart damage happens with alcohol usage and problems include cardiomyopathy; the stretching and drooping of the heart muscle, arrhythmia; irregular heart beat, stroke, and high blood pressure. The liver can become fatty, develop alcoholic hepatitis, fibrosis, and cirrhosis. Alcohol causes the pancreas to produce toxic substances that lead to pancreatitis.
Cancers of the mouth, esophagus, throat, liver, and breast are common with alcohol abuse. Continuous drinking also weakens the immune system, making your body an easy target for disease.
Consuming alcohol in appropriate amounts will lessen your chances of obtaining one of these diseases, and can even help you. Small amounts can even be healthy for you.